Regression models for continuous outcome data - least squares estimates and their properties, interpreting coefficients, prediction, comparing models, checking model assumptions, transformations, outliers, and influential points. Categorical explanatory variables - interaction and analysis of covariance, correlation and partial correlation. Appropriate graphical methods and statistical computing. Analysis of variance for one- and two-factor models - F tests, assumption checking, multiple comparisons. Random effects models and variance components. Introduction to repeated measures models.